Dr. Krystal T. Hamorsky

Dr. Krystal T. HamorskyDr. Krystal T. Hamorsky
Assistant Professor of Chemistry
[email protected]
270-852-3166
Hahn 220

 

 

 


 

Education

B.S., Chemistry, Kentucky Wesleyan College, 2004
Ph.D., Bioanalytical Chemistry, University of Kentucky, 2010

Courses Taught

  • General Chemistry I Lab
  • Concepts of Chemistry
  • Analytical Chemistry

Publications:

Rowe L, Teasley K, Dikici E, Qu X, Ensor M, Deo S, Daunert S. Recombinant Aequorin-Based Systems for Biomarker Analysis. Editor(s): Marks, Robert S. Handbook of Biosensors and Biochips, John Wiley & Sons, 1:173-186, 2007.

Teasley Hamorsky K, Ensor CM, Wei Y, Daunert S. A Bioluminescent Molecular Switch for Glucose. Angewandte Chemie, International Edition 47(20): 3718-3721, 2008.

Teasley Hamorsky K, Dikici E, Ensor CM, Daunert S. Biotechnological Improvements of Bioluminescent Systems. Editor(s): Roda, Aldo. Analytical Chemiluminescence and Bioluminescence: past, present and future, Royal Society of Chemistry, 1:443-487, 2010.

Scott D, Teasley Hamorsky K, Ensor CM, Anderson K, Daunert S. Cyclic AMP Receptor Protein-Aequorin Molecular Switch for Cyclic AMP. Bioconjugate Chemistry 22(3): 475-481, 2011.

Teasley Hamorsky K, Ensor CM, Pasini P, Daunert S. A Protein Switch Sensing System for the Quantification of Sulfate. Analytical Biochemistry 421(1): 172-180, 2012.

Teasley Hamorsky K, Ensor C, Pasini P, Daunert S. Bioluminescence Inhibition Assay for the Detection of Hydroxylated PCBs. Analytical Chemistry 84(18): 7648-55, 2012.

Hamorsky KT, Grooms-Williams T, Husk A, Bennett L, Palmer K, Matoba N. Efficient single tobamoviral vector-based bioproduction of broadly neutralizing anti-HIV-1 monoclonal antibody VRC01 in Nicotiana plants and its utility in combination microbicides. Antimicrobial Agents and Chemotherapy 57(5): 2076-86, 2013.

Hamorsky KT, Kouokam JC, Bennett L, Baldauf KJ, Kajiura H, Fujiyama K, Matoba N. Rapid and Scalable Plant-based Production of a Cholera Toxin B Subunit Variant to Aid in Mass Vaccination against Cholera Outbreaks. PLoS Neglected Tropical Diseases e2046, 2013.

Husk A., Hamorsky KT, Matoba N. Monoclonal Antibody Purification (Nicotiana Benthamiana Plants). Bio-protocol.org. 4(2): http://www.bio-protocol.org/wenzhang.aspx?id=1034, 2014.

Hamorsky KT, Kouokam JC, McMullen J, Nelson B, Bennett L, Husk A, Kajiura H, Fujiyama K, Matoba N. N-Glycosylation of cholera toxin B subunit in Nicotiana benthamiana: impacts on host stress response, production yield and vaccine potential. Scientific Reports Jan 23;5:8003. doi: 10.1038/srep08003, 2015.

Baldauf KJ, Royal JM, Hamorsky KT, Matoba N. Cholera toxin B: One subunit with many pharmaceutical applications. Toxins (Basel) 7(3):974-996, 2015.

Fuqua J, Hamorsky KT, Khalsa G, Matoba N, Palmer KE. Application of Infectious Tobacco Mosaic Virus Vectors for Bulk Production of the Antiviral Lectin Griffithsin. Plant Biotechnology Journal Jul 14; doi: 10.1111/pbi.12433, 2015.

Moore L, *Hamorsky KT, Matoba N. GENEWARE® tobacco mosaic virus vector-based production and purification of recombinant cholera toxin B subunit in Nicotiana benthamiana. Methods in Molecular Biology doi:10.1007/978-1-4939-3289-4_9, 2016.

Hamorsky KT, Matoba N. Facile method for the production of recombinant cholera toxin B subunit in E. coli. Methods in Molecular Biology doi: 10.1007/978-1-4939-3389-1_33, 2016.

Baldauf KJ, Royal JM, Kouokam JC, Haribabu B, Jala VR, Hamorsky KT, Dryden GW, MatobaN. Oral administration of a recombinant cholera toxin B subunit enhances colonic mucosal wound healing. Mucosal Immunology Oct 20;doi:10.1038/mi.2016.95, 2016.

Hamorsky KT, Ensor CM, Dikici E, Pasini P, Bachas L, Daunert S. Investigating the Mechanism of the Inhibition of Bioluminescence of Photoprotein, Aequorin, by Hydroxylated Polychlorinated Biphenyls. Manuscript in preparation, 2017.

Hamorsky KT, Moore L, Wang L, Rohan L, Palmer K, Matoba N. Quality Studies to Support the Biopharmaceutical Development of the Rectal Microbicide Candidate Griffithsin. Manuscript in preparation, 2017.

Hamorsky KT, Kouokam JC, Husk A, Grooms-Williams T, Morris MK, Hanson CV, Hume S, Bratcher B, Vausselin T, Lavie M, Dubuisson J, Tanaka H, Matoba N. A lectibody targeting HIV and cancer-associated high-mannose glycans. Manuscript in preparation, 2017.

Research Interests:

I am interested in drug development of biologics for diagnosis, mitigation, treatment, or prevention of disease. Specifically, advancing protein-based biosensors for the detection of infectious disease and addressing developmental issues in new biopharmaceuticals such as formulation and analytical methodologies.